What is molybdenum most commonly used for?

Transcript :

If you want to learn more, please visit our website YOUBO.

Chemistry in its element: molybdenum

Promo)

You're listening to Chemistry in its element brought to you by Chemistry World, the magazine of the Royal Society of Chemistry.

(End promo)

Meera Senthilingam

This week, we clarify the importance of the often misunderstood molybdenum. Here's Quentin Cooper:

Quentin Cooper

The answer to the ultimate question - of life, the Universe and Everything - is, as every Douglas Adams fan knows, 42. And 42, as every Mendeleev fan knows, is the atomic number of molybdenum. And for many that - plus the indisputable fact that molybdenum is a funny word - is often about as far as their knowledge goes of this silvery metal - not that they'd have known it was a silvery metal - which is wedged between its better known brethren chromium and tungsten in group six of the periodic table. That odd-sounding name comes in a convoluted way from the Greek for lead, as ores of the two were often mixed up by early mineralogists - it was also frequently mistaken for graphite - and it wasn't until that molybdenum was recognised as a distinct entity deserving its own place in the periodic table, and a few years later still that it was finally isolated. The key breakthrough came from the Swedish chemist Carl Wilhlelm Scheele, better known as 'Hard luck Scheele' because he made a whole series of chemical discoveries, including oxygen, only for others to go and get the credit.

So its mistaken-identity history, its miscredited discoverer, its misleading and often mis-spelled name, all add to the aura of comedy and confusion around molybdenum.....and yet it's an element that's right at the root of life - not just human life, but pretty much all life on the planet: yes you'll find tiny amounts of it in everything from the filaments of electric heaters to missiles to protective coatings in boilers, and its high performance at high temperatures mean it has a range of commercial applications: it's useful in toughening up steel and giving it more corrosion resistance, as a catalyst in processes such as refining petroleum, and above all it's turned to when you need things to get hot but stay slippy - where WD40 and other petroleum derived oils are at risk of igniting, molybdenum sulfides are the basis of a range of lubricants which can cope with the heat and keep things moving smoothly.

But for all the ways we've discovered to use it, of far greater significance - although involving far smaller quantities of molybdenum - is the way we've evolved to make use of it within us. It's found in dozens of enzymes... including all important nitrogenase, which allows the most abundant element in the atmosphere, nitrogen, to be taken up and turned into compounds that enable bacteria, plants, us and everything between to synthesise and utilise proteins. Without proteins there wouldn't be much at all in the way of life....and without molybdenum there wouldn't be much at all in the way of proteins. And it turns up in other key human enzymes too such as xanthine oxidase in the liver, which is vital to our waste processing.

But just in case anyone's thinking of rushing off to buy one of the many commercially available trace mineral supplements with molybdenum it's worth adding that although like much of life on Earth we definitely need it.... we don't need that much of it: about a third of a gram is all you'll get through in an entire lifetime. That's next to nothing...but without it we'd be next to nothingness.

So, time to stop laughing at the funny name... molybdenum really is one of life's few true essentials.

Meera Senthilingham

So time to give some much-owed respect, it seems, to the element molybdenum. That was science broadcaster Quentin Cooper with the widely applied chemistry of molybdenum. Now, next week, blink and you may miss it.

Brian Clegg

If elements were insects, darmstadtium would be the mayfly of the chemical world. It exists for the most fleeting time before it transforms to something else. Darmstadium is never going to have a practical use - but its sheer brevity of existence gives it a wistful fascination.

Meera Senthilingham

And to find out what does happen in darmstadtium's brief existence on earth, in next week's Chemistry in its element. Until then, I'm Meera Senthilingham and thank you for listening.

(Promo)

Chemistry in its element is brought to you by the Royal Society of Chemistry and produced by thenakedscientists.com . There's more information and other episodes of Chemistry in its element on our website at chemistryworld.org/elements

(End promo)

Chemical element with atomic number 42 (Mo)

Molybdenum is a chemical element; it has symbol Mo (from Neo-Latin molybdaenum) and atomic number 42. The name derived from Ancient Greek Μόλυβδος molybdos, meaning lead, since its ores were confused with lead ores.[9] Molybdenum minerals have been known throughout history, but the element was discovered (in the sense of differentiating it as a new entity from the mineral salts of other metals) in by Carl Wilhelm Scheele. The metal was first isolated in by Peter Jacob Hjelm.[10]

Molybdenum does not occur naturally as a free metal on Earth; in its minerals, it is found only in oxidized states. The free element, a silvery metal with a grey cast, has the sixth-highest melting point of any element. It readily forms hard, stable carbides in alloys, and for this reason most of the world production of the element (about 80%) is used in steel alloys, including high-strength alloys and superalloys.

Most molybdenum compounds have low solubility in water. Heating molybdenum-bearing minerals under oxygen and water affords molybdate ion MoO2&#;
4, which forms quite soluble salts. Industrially, molybdenum compounds (about 14% of world production of the element) are used as pigments and catalysts.

Molybdenum-bearing enzymes are by far the most common bacterial catalysts for breaking the chemical bond in atmospheric molecular nitrogen in the process of biological nitrogen fixation. At least 50 molybdenum enzymes are now known in bacteria, plants, and animals, although only bacterial and cyanobacterial enzymes are involved in nitrogen fixation. Most nitrogenases contain an iron&#;molybdenum cofactor FeMoco, which is believed to contain either Mo(III) or Mo(IV).[11][12] By contrast Mo(VI) and Mo(IV) are complexed with molybdopterin in all other molybdenum-bearing enzymes.[13] Molybdenum is an essential element for all higher eukaryote organisms, including humans.

Characteristics

[

edit

]

Physical properties

[

edit

]

In its pure form, molybdenum is a silvery-grey metal with a Mohs hardness of 5.5 and a standard atomic weight of 95.95 g/mol.[14][15] It has a melting point of 2,623 °C (4,753 °F), sixth highest of the naturally occurring elements; only tantalum, osmium, rhenium, tungsten, and carbon have higher melting points.[9] It has one of the lowest coefficients of thermal expansion among commercially used metals.[16]

Chemical properties

[

edit

]

Molybdenum is a transition metal with an electronegativity of 2.16 on the Pauling scale. It does not visibly react with oxygen or water at room temperature, but is attacked by halogens and hydrogen peroxide. Weak oxidation of molybdenum starts at 300 °C (572 °F); bulk oxidation occurs at temperatures above 600 °C, resulting in molybdenum trioxide. Like many heavier transition metals, molybdenum shows little inclination to form a cation in aqueous solution, although the Mo3+ cation is known to form under carefully controlled conditions.[17]

Gaseous molybdenum consists of the diatomic species Mo2. That molecule is a singlet, with two unpaired electrons in bonding orbitals, in addition to 5 conventional bonds. The result is a sextuple bond.[18][19]

Isotopes

[

edit

]

There are 39 known isotopes of molybdenum, ranging in atomic mass from 81 to 119, as well as 13 metastable nuclear isomers. Seven isotopes occur naturally, with atomic masses of 92, 94, 95, 96, 97, 98, and 100. Of these naturally occurring isotopes, only molybdenum-100 is unstable.[7]

Molybdenum-98 is the most abundant isotope, comprising 24.14% of all molybdenum. Molybdenum-100 has a half-life of about  y and undergoes double beta decay into ruthenium-100. All unstable isotopes of molybdenum decay into isotopes of niobium, technetium, and ruthenium. Of the synthetic radioisotopes, the most stable is 93Mo, with a half-life of 4,839 years.[8]

The most common isotopic molybdenum application involves molybdenum-99, which is a fission product. It is a parent radioisotope to the short-lived gamma-emitting daughter radioisotope technetium-99m, a nuclear isomer used in various imaging applications in medicine.[20] In , the Delft University of Technology applied for a patent on the molybdenum-98-based production of molybdenum-99.[21]

Compounds

[

edit

]

Molybdenum forms chemical compounds in oxidation states &#;4 and from &#;2 to +6. Higher oxidation states are more relevant to its terrestrial occurrence and its biological roles, mid-level oxidation states are often associated with metal clusters, and very low oxidation states are typically associated with organomolybdenum compounds. The chemistry of molybdenum and tungsten show strong similarities. The relative rarity of molybdenum(III), for example, contrasts with the pervasiveness of the chromium(III) compounds. The highest oxidation state is seen in molybdenum(VI) oxide (MoO3), whereas the normal sulfur compound is molybdenum disulfide MoS2.[22]

Keggin structure of the phosphomolybdate anion (P[Mo12O40]3&#;), an example of a polyoxometalate

From the perspective of commerce, the most important compounds are molybdenum disulfide (MoS
2) and molybdenum trioxide (MoO
3). The black disulfide is the main mineral. It is roasted in air to give the trioxide:[22]

2

MoS

2

+ 7

O

2

&#; 2

MoO

3

+ 4

SO

2

The trioxide, which is volatile at high temperatures, is the precursor to virtually all other Mo compounds as well as alloys. Molybdenum has several oxidation states, the most stable being +4 and +6 (bolded in the table at left).

Molybdenum(VI) oxide is soluble in strong alkaline water, forming molybdates (MoO42&#;). Molybdates are weaker oxidants than chromates. They tend to form structurally complex oxyanions by condensation at lower pH values, such as [Mo7O24]6&#; and [Mo8O26]4&#;. Polymolybdates can incorporate other ions, forming polyoxometalates.[26] The dark-blue phosphorus-containing heteropolymolybdate P[Mo12O40]3&#; is used for the spectroscopic detection of phosphorus.[27]

The broad range of oxidation states of molybdenum is reflected in various molybdenum chlorides:[22]

• Molybdenum(II) chloride MoCl2, which exists as the hexamer Mo6Cl12 and the related dianion [Mo6Cl14]2-.
• Molybdenum(III) chloride MoCl3, a dark red solid, which converts to the anion trianionic complex [MoCl6]3-.
• Molybdenum(IV) chloride MoCl4, a black solid, which adopts a polymeric structure.
• Molybdenum(V) chloride MoCl5 dark green solid, which adopts a dimeric structure.
• Molybdenum(VI) chloride MoCl6 is a black solid, which is monomeric and slowly decomposes to MoCl5 and Cl2 at room temperature.

  [

  28

  ]

The accessibility of these oxidation states depends quite strongly on the halide counterion: although molybdenum(VI) fluoride is stable, molybdenum does not form a stable hexachloride, pentabromide, or tetraiodide.[29]

Like chromium and some other transition metals, molybdenum forms quadruple bonds, such as in Mo2(CH3COO)4 and [Mo2Cl8]4&#;.[22][30] The Lewis acid properties of the butyrate and perfluorobutyrate dimers, Mo2(O2CR)4 and Rh2(O2CR) 4, have been reported.[31]

The oxidation state 0 and lower are possible with carbon monoxide as ligand, such as in molybdenum hexacarbonyl, Mo(CO)6.[22][24]

History

[

edit

]

Molybdenite&#;the principal ore from which molybdenum is now extracted&#;was previously known as molybdena. Molybdena was confused with and often utilized as though it were graphite. Like graphite, molybdenite can be used to blacken a surface or as a solid lubricant.[32] Even when molybdena was distinguishable from graphite, it was still confused with the common lead ore PbS (now called galena); the name comes from Ancient Greek Μόλυβδος molybdos, meaning lead.[16] (The Greek word itself has been proposed as a loanword from Anatolian Luvian and Lydian languages).[33]

Although (reportedly) molybdenum was deliberately alloyed with steel in one 14th-century Japanese sword (mfd. c.&#;), that art was never employed widely and was later lost.[34][35] In the West in , Bengt Andersson Qvist examined a sample of molybdenite and determined that it did not contain lead and thus was not galena.[36]

By Swedish chemist Carl Wilhelm Scheele stated firmly that molybdena was (indeed) neither galena nor graphite.[37][38] Instead, Scheele correctly proposed that molybdena was an ore of a distinct new element, named molybdenum for the mineral in which it resided, and from which it might be isolated. Peter Jacob Hjelm successfully isolated molybdenum using carbon and linseed oil in .[16][39]

For the next century, molybdenum had no industrial use. It was relatively scarce, the pure metal was difficult to extract, and the necessary techniques of metallurgy were immature.[40][41][42] Early molybdenum steel alloys showed great promise of increased hardness, but efforts to manufacture the alloys on a large scale were hampered with inconsistent results, a tendency toward brittleness, and recrystallization. In , William D. Coolidge filed a patent for rendering molybdenum ductile, leading to applications as a heating element for high-temperature furnaces and as a support for tungsten-filament light bulbs; oxide formation and degradation require that molybdenum be physically sealed or held in an inert gas.[43] In , Frank E. Elmore developed a froth flotation process to recover molybdenite from ores; flotation remains the primary isolation process.[44]

During World War I, demand for molybdenum spiked; it was used both in armor plating and as a substitute for tungsten in high-speed steels. Some British tanks were protected by 75 mm (3 in) manganese steel plating, but this proved to be ineffective. The manganese steel plates were replaced with much lighter 25 mm (1.0 in) molybdenum steel plates allowing for higher speed, greater maneuverability, and better protection.[16] The Germans also used molybdenum-doped steel for heavy artillery, like in the super-heavy howitzer Big Bertha,[45] because traditional steel melts at the temperatures produced by the propellant of the one ton shell.[46] After the war, demand plummeted until metallurgical advances allowed extensive development of peacetime applications. In World War II, molybdenum again saw strategic importance as a substitute for tungsten in steel alloys.[47]

Occurrence and production

[

edit

]

Molybdenite on quartz

Molybdenum is the 54th most abundant element in the Earth's crust with an average of 1.5 parts per million and the 25th most abundant element and most abundant transition metal in the oceans, with an average of 10 parts per billion; it is the 42nd most abundant element in the Universe.[16][48] The Soviet Luna 24 mission discovered a molybdenum-bearing grain (1 × 0.6 μm) in a pyroxene fragment taken from Mare Crisium on the Moon.[49] The comparative rarity of molybdenum in the Earth's crust is offset by its concentration in a number of water-insoluble ores, often combined with sulfur in the same way as copper, with which it is often found. Though molybdenum is found in such minerals as wulfenite (PbMoO4) and powellite (CaMoO4), the main commercial source is molybdenite (MoS2). Molybdenum is mined as a principal ore and is also recovered as a byproduct of copper and tungsten mining.[9]

The world's production of molybdenum was 250,000 tonnes in , the largest producers being China (94,000 t), the United States (64,000 t), Chile (38,000 t), Peru (18,000 t) and Mexico (12,000 t). The total reserves are estimated at 10 million tonnes, and are mostly concentrated in China (4.3 Mt), the US (2.7 Mt) and Chile (1.2 Mt). By continent, 93% of world molybdenum production is about evenly shared between North America, South America (mainly in Chile), and China. Europe and the rest of Asia (mostly Armenia, Russia, Iran and Mongolia) produce the remainder.[50]

The company is the world’s best Molybdenum Powder Uses supplier. We are your one-stop shop for all needs. Our staff are highly-specialized and will help you find the product you need.

World production trend

In molybdenite processing, the ore is first roasted in air at a temperature of 700 °C (1,292 °F). The process gives gaseous sulfur dioxide and the molybdenum(VI) oxide:[22]

2 MoS 2 + 7 O 2 &#; 2 MoO 3 + 4 SO 2 {\displaystyle {\ce {2MoS2 + 7O2 -> 2MoO3 + 4SO2}}}

The resulting oxide is then usually extracted with aqueous ammonia to give ammonium molybdate:

MoO 3 + 2 NH 3 + H 2 O &#; ( NH 4 ) 2 ( MoO 4 ) {\displaystyle {\ce {MoO3 + 2NH3 + H2O -> (NH4)2(MoO4)}}}

Copper, an impurity in molybdenite, is separated at this stage by treatment with hydrogen sulfide.[22] Ammonium molybdate converts to ammonium dimolybdate, which is isolated as a solid. Heating this solid gives molybdenum trioxide:[51]

( NH 4 ) 2 Mo 2 O 7 &#; 2 MoO 3 + 2 NH 3 + H 2 O {\displaystyle {\ce {(NH4)2Mo2O7 -> 2MoO3 + 2NH3 + H2O}}}

Crude trioxide can be further purified by sublimation at 1,100 °C (2,010 °F).

Metallic molybdenum is produced by reduction of the oxide with hydrogen:

MoO 3 + 3 H 2 &#; Mo + 3 H 2 O {\displaystyle {\ce {MoO3 + 3H2 -> Mo + 3H2O}}}

The molybdenum for steel production is reduced by the aluminothermic reaction with addition of iron to produce ferromolybdenum. A common form of ferromolybdenum contains 60% molybdenum.[22][52]

Molybdenum had a value of approximately $30,000 per tonne as of August . It maintained a price at or near $10,000 per tonne from through , and reached a peak of $103,000 per tonne in June .[53] In , the London Metal Exchange announced that molybdenum would be traded as a commodity.[54]

Mining

[

edit

]

The Knaben mine in southern Norway, opened in , was the first dedicated molybdenum mine. Closed in but reopened in ,[55] it now produces 100,000 kilograms (98 long tons; 110 short tons) of molybdenum disulfide per year. Large mines in Colorado (such as the Henderson mine and the Climax mine)[56] and in British Columbia yield molybdenite as their primary product, while many porphyry copper deposits such as the Bingham Canyon Mine in Utah and the Chuquicamata mine in northern Chile produce molybdenum as a byproduct of copper-mining.

Applications

[

edit

]

Alloys

[

edit

]

A plate of molybdenum copper alloy

About 86% of molybdenum produced is used in metallurgy, with the rest used in chemical applications. The estimated global use is structural steel 35%, stainless steel 25%, chemicals 14%, tool & high-speed steels 9%, cast iron 6%, molybdenum elemental metal 6%, and superalloys 5%.[57]

Molybdenum can withstand extreme temperatures without significantly expanding or softening, making it useful in environments of intense heat, including military armor, aircraft parts, electrical contacts, industrial motors, and supports for filaments in light bulbs.[16][58]

Most high-strength steel alloys (for example, 41xx steels) contain 0.25% to 8% molybdenum.[9] Even in these small portions, more than 43,000 tonnes of molybdenum are used each year in stainless steels, tool steels, cast irons, and high-temperature superalloys.[48]

Molybdenum is also used in steel alloys for its high corrosion resistance and weldability.[48][50] Molybdenum contributes corrosion resistance to type-300 stainless steels (specifically type-316) and especially so in the so-called superaustenitic stainless steels (such as alloy AL-6XN, 254SMO and hMo). Molybdenum increases lattice strain, thus increasing the energy required to dissolve iron atoms from the surface.[contradictory] Molybdenum is also used to enhance the corrosion resistance of ferritic (for example grade 444)[59] and martensitic (for example 1. and 1.) stainless steels.[citation needed]

Because of its lower density and more stable price, molybdenum is sometimes used in place of tungsten.[48] An example is the 'M' series of high-speed steels such as M2, M4 and M42 as substitution for the 'T' steel series, which contain tungsten. Molybdenum can also be used as a flame-resistant coating for other metals. Although its melting point is 2,623 °C (4,753 °F), molybdenum rapidly oxidizes at temperatures above 760 °C (1,400 °F) making it better-suited for use in vacuum environments.[58]

TZM (Mo (~99%), Ti (~0.5%), Zr (~0.08%) and some C) is a corrosion-resisting molybdenum superalloy that resists molten fluoride salts at temperatures above 1,300 °C (2,370 °F). It has about twice the strength of pure Mo, and is more ductile and more weldable, yet in tests it resisted corrosion of a standard eutectic salt (FLiBe) and salt vapors used in molten salt reactors for hours with so little corrosion that it was difficult to measure.[60][61] Due to its excellent mechanical properties under high temperature and high pressure, TZM alloys are extensively applied in the military industry.[62] It is used as the valve body of torpedo engines, rocket nozzles and gas pipelines, where it can withstand extreme thermal and mechanical stresses.[63][64] It is also used as radiation shields in nuclear applications.[65]

Other molybdenum-based alloys that do not contain iron have only limited applications. For example, because of its resistance to molten zinc, both pure molybdenum and molybdenum-tungsten alloys (70%/30%) are used for piping, stirrers and pump impellers that come into contact with molten zinc.[66]

Pure element applications

[

edit

]

Compound applications

[

edit

]

Biological role

[

edit

]

Mo-containing enzymes

[

edit

]

Molybdenum is an essential element in most organisms; a research paper speculated that a scarcity of molybdenum in the Earth's early oceans may have strongly influenced the evolution of eukaryotic life (which includes all plants and animals).[81]

At least 50 molybdenum-containing enzymes have been identified, mostly in bacteria.[82][83] Those enzymes include aldehyde oxidase, sulfite oxidase and xanthine oxidase.[16] With one exception, Mo in proteins is bound by molybdopterin to give the molybdenum cofactor. The only known exception is nitrogenase, which uses the FeMoco cofactor, which has the formula Fe7MoS9C.[84]

In terms of function, molybdoenzymes catalyze the oxidation and sometimes reduction of certain small molecules in the process of regulating nitrogen, sulfur, and carbon.[85] In some animals, and in humans, the oxidation of xanthine to uric acid, a process of purine catabolism, is catalyzed by xanthine oxidase, a molybdenum-containing enzyme. The activity of xanthine oxidase is directly proportional to the amount of molybdenum in the body. An extremely high concentration of molybdenum reverses the trend and can inhibit purine catabolism and other processes. Molybdenum concentration also affects protein synthesis, metabolism, and growth.[86]

Mo is a component in most nitrogenases. Among molybdoenzymes, nitrogenases are unique in lacking the molybdopterin.[87][88] Nitrogenases catalyze the production of ammonia from atmospheric nitrogen:

N 2 + 8   H + + 8   e &#; + 16   A T P + 16   H 2 O &#; 2   N H 3 + H 2 + 16   A D P + 16   P i {\displaystyle \mathrm {N_{2}+8\ H^{+}+8\ e^{-}+16\ ATP+16\ H_{2}O\longrightarrow 2\ NH_{3}+H_{2}+16\ ADP+16\ P_{i}} }

The biosynthesis of the FeMoco active site is highly complex.[89]

Structure of the FeMoco active site of nitrogenase The molybdenum cofactor (pictured) is composed of a molybdenum-free organic complex called molybdopterin, which has bound an oxidized molybdenum(VI) atom through adjacent sulfur (or occasionally selenium) atoms. Except for the ancient nitrogenases, all known Mo-using enzymes use this cofactor.

Molybdate is transported in the body as MoO42&#;.[86]

Human metabolism and deficiency

[

edit

]

Molybdenum is an essential trace dietary element.[90] Four mammalian Mo-dependent enzymes are known, all of them harboring a pterin-based molybdenum cofactor (Moco) in their active site: sulfite oxidase, xanthine oxidoreductase, aldehyde oxidase, and mitochondrial amidoxime reductase.[91] People severely deficient in molybdenum have poorly functioning sulfite oxidase and are prone to toxic reactions to sulfites in foods.[92][93] The human body contains about 0.07 mg of molybdenum per kilogram of body weight,[94] with higher concentrations in the liver and kidneys and lower in the vertebrae.[48] Molybdenum is also present within human tooth enamel and may help prevent its decay.[95]

Acute toxicity has not been seen in humans, and the toxicity depends strongly on the chemical state. Studies on rats show a median lethal dose (LD50) as low as 180 mg/kg for some Mo compounds.[96] Although human toxicity data is unavailable, animal studies have shown that chronic ingestion of more than 10 mg/day of molybdenum can cause diarrhea, growth retardation, infertility, low birth weight, and gout; it can also affect the lungs, kidneys, and liver.[97][98] Sodium tungstate is a competitive inhibitor of molybdenum. Dietary tungsten reduces the concentration of molybdenum in tissues.[48]

Low soil concentration of molybdenum in a geographical band from northern China to Iran results in a general dietary molybdenum deficiency and is associated with increased rates of esophageal cancer.[99][100][101] Compared to the United States, which has a greater supply of molybdenum in the soil, people living in those areas have about 16 times greater risk for esophageal squamous cell carcinoma.[102]

Molybdenum deficiency has also been reported as a consequence of non-molybdenum supplemented total parenteral nutrition (complete intravenous feeding) for long periods of time. It results in high blood levels of sulfite and urate, in much the same way as molybdenum cofactor deficiency. Since pure molybdenum deficiency from this cause occurs primarily in adults, the neurological consequences are not as marked as in cases of congenital cofactor deficiency.[103]

A congenital molybdenum cofactor deficiency disease, seen in infants, is an inability to synthesize molybdenum cofactor, the heterocyclic molecule discussed above that binds molybdenum at the active site in all known human enzymes that use molybdenum. The resulting deficiency results in high levels of sulfite and urate, and neurological damage.[104][105]

Excretion

[

edit

]

Most molybdenum is excreted from the human body as molybdate in the urine. Furthermore, urinary excretion of molybdenum increases as dietary molybdenum intake increases. Small amounts of molybdenum are excreted from the body in the feces by way of the bile; small amounts also can be lost in sweat and in hair.[106][107]

Excess and copper antagonism

[

edit

]

High levels of molybdenum can interfere with the body's uptake of copper, producing copper deficiency. Molybdenum prevents plasma proteins from binding to copper, and it also increases the amount of copper that is excreted in urine. Ruminants that consume high levels of molybdenum suffer from diarrhea, stunted growth, anemia, and achromotrichia (loss of fur pigment). These symptoms can be alleviated by copper supplements, either dietary and injection.[108] The effective copper deficiency can be aggravated by excess sulfur.[48][109]

Copper reduction or deficiency can also be deliberately induced for therapeutic purposes by the compound ammonium tetrathiomolybdate, in which the bright red anion tetrathiomolybdate is the copper-chelating agent. Tetrathiomolybdate was first used therapeutically in the treatment of copper toxicosis in animals. It was then introduced as a treatment in Wilson's disease, a hereditary copper metabolism disorder in humans; it acts both by competing with copper absorption in the bowel and by increasing excretion. It has also been found to have an inhibitory effect on angiogenesis, potentially by inhibiting the membrane translocation process that is dependent on copper ions.[110] This is a promising avenue for investigation of treatments for cancer, age-related macular degeneration, and other diseases that involve a pathologic proliferation of blood vessels.[111][112]

In some grazing livestock, most strongly in cattle, molybdenum excess in the soil of pasturage can produce scours (diarrhea) if the pH of the soil is neutral to alkaline; see teartness.

Dietary recommendations

[

edit

]

In , the then U.S. Institute of Medicine (now the National Academy of Medicine, NAM) updated its Estimated Average Requirements (EARs) and Recommended Dietary Allowances (RDAs) for molybdenum. If there is not sufficient information to establish EARs and RDAs, an estimate designated Adequate Intake (AI) is used instead.

An AI of 2 micrograms (μg) of molybdenum per day was established for infants up to 6 months of age, and 3 μg/day from 7 to 12 months of age, both for males and females. For older children and adults, the following daily RDAs have been established for molybdenum: 17 μg from 1 to 3 years of age, 22 μg from 4 to 8 years, 34 μg from 9 to 13 years, 43 μg from 14 to 18 years, and 45 μg for persons 19 years old and older. All these RDAs are valid for both sexes. Pregnant or lactating females from 14 to 50 years of age have a higher daily RDA of 50 μg of molybdenum.

As for safety, the NAM sets tolerable upper intake levels (ULs) for vitamins and minerals when evidence is sufficient. In the case of molybdenum, the UL is  μg/day. Collectively the EARs, RDAs, AIs and ULs are referred to as Dietary Reference Intakes (DRIs).[113]

The European Food Safety Authority (EFSA) refers to the collective set of information as Dietary Reference Values, with Population Reference Intake (PRI) instead of RDA, and Average Requirement instead of EAR. AI and UL are defined the same as in the United States. For women and men ages 15 and older, the AI is set at 65 μg/day. Pregnant and lactating women have the same AI. For children aged 1&#;14 years, the AIs increase with age from 15 to 45 μg/day. The adult AIs are higher than the U.S. RDAs,[114] but on the other hand, the European Food Safety Authority reviewed the same safety question and set its UL at 600 μg/day, which is much lower than the U.S. value.[115]

Labeling

[

edit

]

For U.S. food and dietary supplement labeling purposes, the amount in a serving is expressed as a percent of Daily Value (%DV). For molybdenum labeling purposes, 100% of the Daily Value was 75 μg, but as of May 27, it was revised to 45 μg.[116][117] A table of the old and new adult daily values is provided at Reference Daily Intake.

Food sources

[

edit

]

Average daily intake varies between 120 and 240 μg/day, which is higher than dietary recommendations.[97] Pork, lamb, and beef liver each have approximately 1.5 parts per million of molybdenum. Other significant dietary sources include green beans, eggs, sunflower seeds, wheat flour, lentils, cucumbers, and cereal grain.[16]

Precautions

[

edit

]

Molybdenum dusts and fumes, generated by mining or metalworking, can be toxic, especially if ingested (including dust trapped in the sinuses and later swallowed).[96] Low levels of prolonged exposure can cause irritation to the eyes and skin. Direct inhalation or ingestion of molybdenum and its oxides should be avoided.[118][119] OSHA regulations specify the maximum permissible molybdenum exposure in an 8-hour day as 5 mg/m3. Chronic exposure to 60 to 600 mg/m3 can cause symptoms including fatigue, headaches and joint pains.[120] At levels of  mg/m3, molybdenum is immediately dangerous to life and health.[121]

See also

[

edit

]

References

[

edit

]

Bibliography

[

edit

]

• Lettera di Giulio Candida al signor Vincenzo Petagna &#; Sulla formazione del molibdeno. Naples: Giuseppe Maria Porcelli. .

For more Molybdenum Rodinformation, please contact us. We will provide professional answers.